The main objective of the strategy is to produce the attention-grabbing a part of the medical image on that completely different treatment is to be enforced. Medical imaging is on the simplest technique for observation the patient health condition. CT or magnetic resonance imaging medical imaging produce digital kind of physical body photos. There exists a desire for compression of those pictures for storage and communication functions. Current compression schemes offer a really high compression rate with a substantial loss of quality. In medication, it's necessary to possess high image quality in region of interest, i.e. diagnostically necessary regions. This work discusses a hybrid model of lossless compression in region of interest with high compression rate, lossy compression in different regions. In medical image once some portion of image is to be selected, and then ROI is chosen with the assistance of discrete cosine transform. It’s used with the ROI method to compress the medical image to get rid of the interference result