The mechanical and thermal properties of plutonium monochalcogenides and monopnictides are calculated using elastic constants and sound velocities, those have been derived from two body inter- ionic potential theory. We have calculated the Young’s modulus (E), Poisson’s ratio (ν), anisotropy factors (A), bulk modulus to shear modulus ratio (B/G) for these compounds. The calculated values of Poisson’s ratio show that the ionic contributions to the atomic bonding are dominant for these compounds. The B/G ratio indicates that, only PuS will behave in the brittle manner and other compounds will show the ductile nature. We have also calculated the sound velocities, Debye temperature (θD), Grüneisen parameter (ς), and lattice heat capacities (β) for these compounds.